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KMID : 1036520160060020019
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Clinical Neuro-Ophthalmology
2016 Volume.6 No. 2 p.19 ~ p.26
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Graves’ Orbitopathy
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Yoon Jin-Sook
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Abstract
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Graves’ orbitopathy (GO) is an autoimmune disease associated with Graves’ hyperthyroidism and affecting the orbital and periorbital tissues. Although the pathogenesis of GO is not clearly understood, thyroid-stimulating hormone receptor antigen expressed on orbital fibroblasts and thyroid follicular cells is considered to be a target co-antigen. Manifestation of GO is proptosis, conjunctival chemosis, periorbital edema, altered ocular motility, and vision-threatening compressive optic neuropathy, all of which bear significant functional, social, and cosmetic consequences. Therefore, appropriate timely therapeutic management should be applied depending on the phase of GO.
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KEYWORD
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Graves’ Orbitopathy, Thyroid, Eye
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